Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications
نویسندگان
چکیده
منابع مشابه
Identification and validation long non-coding RNAs of oral squamous cell carcinoma by bioinformatics method
Gene markers of oral squamous cell carcinoma (OSCC) have great significance on early diagnosis and treatment of clinical oral cancer. In this study, we used RNA-Seq data from OSCC patients and filtered differentially-expressed long non-coding RNA (lncRNA) to further clarify the molecular mechanism. Firstly, we downloaded datasets of OSCC from National Center for Biotechnology Information(NCBI),...
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Protein-coding genes account for only a small fraction of the human genome and most of the genomic sequences are transcriptionally silent, but recent observations indicate significant functional elements, including non-coding protein transcripts in the human genome. Long non-coding RNAs (lncRNAs) have been defined as transcripts of >200 nucleotides without protein-coding capacity that perform t...
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ژورنال
عنوان ژورنال: Molecular Cancer
سال: 2019
ISSN: 1476-4598
DOI: 10.1186/s12943-019-1021-3